| Brand Name: |
Parit |
| Generic Name: |
Rabeprazole |
| Form: |
Tablets |
| Manufacturer: |
Biocon |
What is Parit?
Parit (Rabeprazole) is classified as the proton pump inhibitor and is used to treat the following disorders:
- Gastric ulcer and duodenal ulcer in the exacerbation phase;
- Gastroesophageal reflux disease;
- Hydrochloric acid hypersecretory disorders, including Zollinger-Ellison syndrome;
- Helicobacter pylori eradication in patients with gastric ulcer and chronic gastritis (only in combination with the antibiotics);
- Ulcer disease relapses, associated with Helicobacter pylori (only in combination with the antibiotics).
How is Parit used?
Parit (Rabeprazole) tablets are swallowed whole without chewing or crushing them. The doses and the duration of the treatment depend on the disease:
Gastric ulcer in the exacerbation phase - 20mg once per day for 4 weeks, when healing is slow the treatment should be extended by additional 4 weeks.
Duodenal ulcer - 10 or 20mg once per day for 6 weeks, when healing is slow the treatment should be extended by additional 6 weeks.
Gastroesophageal reflux disease - 20mg once per day for 4-8 weeks, subsequent maintenance therapy of 10-20mg once per day can be prescribed later on.
Helicobacter pylori eradication as part of the triple therapy: 20mg of Rabeprazole twice per day, 500 mg of Clarithromycin per day and 1,000mg of Amoxycillin per day for 7 days (other eradication regimens are also possible).
The time of administration and the time of meals do not affect the effectiveness of the medication, however it’s is considered that the patients are more committed to the treatment when it’s taken in the morning before a meal (with once per day administration).
Adverse effects
Parit (Rabeprazole) may cause the following side effects:
- Digestive system: diarrhea, nausea; less common - vomiting, abdominal pain, flatulence, constipation; rare - dry mouth, burping, dyspepsia; in individual cases - taste disorders, anorexia, stomatitis, gastritis, elevated liver transaminases;
- Nervous system and sense organs: headache; less common - dizziness, asthenia, insomnia; very rare - nervousness, drowsiness; in individual cases - depression, vision disorders;
- Musculo-skeletal system: rare - muscle pain; very rare - joint pain, calf cramps;
- Respiratory system: rare - upper respiratory tract inflammation or infection, severe cough; very rare - sinusitis, bronchitis;
- Allergic reactions: rare - skin rash, skin itching;
- Other: rare - back pain, chest pain, pain in extremities, swelling, urinary tract infection, fever, chills, flu-like syndrome; in individual cases - increased sweating, weight gain, leucocytosis.
Warnings
Before the treatment with Parit (Rabeprazole), it is essential to rule out malignant tumors of the stomach, because symptomatic improvement based on the medication administration may complicate timely diagnosis. It is recommended to exercise caution when this medication is prescribed to patients with severe liver disorders for the first time. In case of drowsiness, patients should avoid driving a car and performing any other similar activities. Patients, taking Ketoconazole and Digoxin, require additional monitoring, as dosage adjustment may be needed for these medications.
Parit (Rabeprazole) contraindications:
- Hypersensitivity to Rabeprazole
- Pregnancy
- Breast feeding
Parit (Rabeprazole) use limitations:
- Severe liver disorders
- Pediatric use
- In case of long term treatment with Rabeprazole in high doses, the risks of hip, wrist, and backbone fractures increases
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